The Transsexual Escort Part 2 The Return of Lola (Book 2)

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Midgut homeostasis is maintained via a basal level of ISC turnover to replace the cells loss during normal gut function ( Antonello et al. A) Relative enrichment of Lola on binding and non-binding ( genebody, gb) regions compared to IgG in control ( Renilla dsRNA treated, gray and black bars) and Lola knockdown cells ( lola dsRNA treated, pink and red bars) were analyzed by ChIP and real-time PCR. Similarly, inactivation of Hippo signaling also causes enhanced ISC proliferation, indicating the possibility that Lola functions downstream of Hippo.

B-E) Representative images of Drosophila adult midguts of esg-Gal4; tubGal80 ts ( esg ts) ( B), esg ts>wts RNAi-2 ( C), esg ts>yki RNAi ( D), and esg ts>yki RNAi; wts RNAi-2 ( E). Our biochemical results provide further insights on possible mechanisms of how Wts controls Lola stability.B–E’) Representative images of Drosophila adult midguts containing GFP positive MARCM clones of control ( B–B’), wts x1 ( C–C’), lola ( D–D’), and wts x1 in the presence of lola ( E–E’).

F) Quantifications of the cell number per clone in adult midguts from the indicated genotypes in B-E at 2, 4, and 6 days after clone induction (***p<0. E) Quantifications of the p-H3 + cell number in adult midguts with the indicated genotypes: MyoIA ts, MyoIA ts>lola, MyoIA ts>wts RNAi, MyoIA ts>lola; wts RNAi, MyoIA ts>wts RNAi, Dref RNAi, and MyoIA ts>wts RNAi, SkpA RNAi (ns p>0.

A-C’) Representative images of Drosophila adult midguts containing GFP positive MARCM clones of control ( A-A’), lola 5D2 (B-B’), and lola 5D2 in the presence of wts ( C-C’).