Solaray, Lithium Aspartate, 5 mg, 100 Capsules

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Although motor symptom progression leads to disability in PD, cognitive impairment with progression to dementia has a greater negative impact on quality of life in PD than motor symptoms, occurs in the majority of PD patients and strongly predicts nursing home placement ( Aarsland et al., 2000; Schrag et al., 2000; Hely et al., 2008; Lawson et al., 2016). On average, it takes about 10 years for dementia to occur after PD diagnosis ( Aarsland and Kurz, 2010), which highlights the need for identification of cognition progression biomarkers that could be used in clinical trials to help identify therapies to slow cognitive decline even in early PD. Recently, our group identified FW progression in the DMN-T and nbM to reflect longitudinal cognitive decline in early PD from PPMI ( Guttuso et al., 2022). Thus, a therapy that slowed FW progression in the DMN-T and nbM in PD would imply that it may be able to slow long-term cognitive decline and prevent dementia. Our findings associating medium-dose lithium aspartate therapy with longitudinal reductions in DMN-T and nbM FW show promise towards these ends. Kousa A, Mattila S, Nikkarinen M (2013) High tech-metals in the environment and health. Lithium and cobalt. Geologian Tutkimuskeskus 53:2–14 It propelled Charles Leiper Grigg’s invention to become one of the bestselling beverages of all time.

Olbrich R, Watzl H, Völter M, Siedow H (March 1991). "Lithium in the treatment of chronic alcoholic patients with brain damage--a controlled study". Nervenarzt. 62 (3): 182–6. PMID 2052117. Ohgami H, Terao T, Shiotsuki I, Ishii N, Iwata N (2009) Lithium levels in drinking water and risk of suicide. Br J Psychiatry 194:464–465 Neuroprotective effects of lithium (Li) have been well documented in tissue cultures and animal models. 1 , 2 It has been suggested that Li has neuroprotective effects in humans, 3 , 4 but the data are still limited. Proton magnetic resonance spectroscopy (MRS) allows for in vivo, noninvasive measurement of concentrations of certain chemicals, including N-acetylaspartate (NAA). N-acetylaspartate is the most dominant proton MRS peak and one of the most abundant amino acids in the brain, where it is predominantly localized in neurons and absent in mature glia. As such, NAA is considered a putative neuronal marker, which is decreased in conditions characterized by loss of neurons or axons, e.g., stroke, Alzheimer dementia, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury and epilepsy. In addition, NAA synthesis is dependent on energy metabolism. Decreased levels of NAA have been used as an indirect marker of neuronal/axonal loss or compromised neuronal metabolism. 5 – 7 At this time, there isn’t enough research to determine what the required daily intake of lithium should be. Dr. Schrauzer, professor at U.C. San Diego and director of the Biological Trace Element Research Institute, has made a provisional recommendation that the daily requirement for lithium should be 1mg/day for an adult of average weight. However, this recommendation does not take into account an individual’s mental health condition or unique biochemical factors. Lithium carbonate– This form can only be obtained as a prescription medication in most countries. A daily dose often contains about 112 to 225 mg of lithium, which is a significantly higher dose than what is found in lithium supplements. Lithium carbonate is about as safe as lithium orotate or aspartate per milligram but it is responsible for significantly more side effects because lithium orotate and aspartate are usually taken at much lower doses.

What is lithium orotate?

Aarsland D., Larsen J.P., Tandberg E., Laake K. Predictors of nursing home placement in Parkinson's disease: a population-based, prospective study. J. Am. Geriatr. Soc. 2000; 48:938–942. [ PubMed] [ Google Scholar] Li T., Yang Z., Li S., Cheng C., Shen B., Le W. Alterations of NURR1 and cytokines in the peripheral blood mononuclear cells: combined biomarkers for Parkinson's disease. Front. Aging Neurosci. 2018; 10:392. [ PMC free article] [ PubMed] [ Google Scholar] Some lithium orotate research found higher concentrations of lithium in the brain of rats that were given lithium orotate vs. carbonate. These findings hint at the possible ability of lithium orotate to cross the blood-brain barrier more efficiently. However, later lithium orotate studies suggested that the experiments used high doses, which might have affected the renal function and clearance, explaining the higher lithium concentrations in the brain. Lithium Orotate vs. Lithium Aspartate Lithium orotate supplements are low-dose and therefore not an effective treatment for clinical depression. As it could help with a variety of different symptoms related to mood swings, it is expected to affect people with depression. Vosahlikova M, Svoboda P (2017) Lithium—therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms. Acta Neurobiol Exp 76:1–19

Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T. NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc. Natl. Acad. Sci. USA. 2010; 107:12317–12322. [ PMC free article] [ PubMed] [ Google Scholar] Williams RSB, Cheng L, Mudge AW, Harwood AJ (2002) A common mechanism of action for three mood-stabilizing drugs. Nature 417:292–295

By Goal

None of the studies performed so far have directly examined the potential relationship between Li contained in solid food and mental health, although some investigations indicate a beneficial effect of dietary Li supplementation on mood [ 53]. Some authors have suggested that optimal Li intake may have a protective effect on the nervous system and have a positive effect on mental health, through the anti-inflammatory and antioxidant effects as well through the regulation of the metabolism of nervous system [ 35]. Lawson R.A., Yarnall A.J., Duncan G.W., Breen D.P., Khoo T.K., Williams-Gray C.H., Barker R.A., Collerton D., Taylor J.P., Burn D.J., group I-Ps Cognitive decline and quality of life in incident Parkinson's disease: the role of attention. Park. Relat. Disord. 2016; 27:47–53. [ PMC free article] [ PubMed] [ Google Scholar]