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Scott LN, Fiume M, Bergfeld WF, et al. Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):77-128. View abstract.
Panthenol is suitable for all skin types including dry, oily, sensitive, combination and irritated skin. Oguz, A., et al.(2015). Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: An experimental study.
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Main Benefits: Binds to and holds water in the skin, moisturizing and leaving it soft, smooth, and more supple. It also has anti-inflammatory properties and is involved in activating the proliferation of cells that are important for wound healing and restoring the function of the skin barrier. Vitamin B5 (pantothenic acid) supplements are not subject to initial review by the U.S. Food and Drug Administration (FDA). The agency does not have the authority to examine dietary supplement products for safety and effectiveness prior to marketing. Out of all the drugs listed in this indications section, only panthenol and dexpanthenol are approved by the FDA for use in cosmetics. All other indications listed are non-FDA approved. A 2016 study also found that dexpanthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration. It also retains or increases molecular fluidity to compensate for reduced hydration. Moreover, it enhances the skin’s permeability to active ingredients in topical products. Soothes and reduces inflammation Synergetic ingredients: Works well with most ingredients but especially well with humectants like hyaluronic acid and occlusive ingredients that help trap the moisture in the skin.
Costa, S. D., Muller, A., Grischke, E. M., Fuchs, A., and Bastert, G. [Postoperative management after cesarean section--infusion therapy and role of intestinal stimulation with parasympathomimetic drugs and dexpanthenon]. Zentralbl.Gynakol. 1994;116(7):375-384. View abstract.Sznurkowska, K., et al. (2015). Irritant diaper dermatitis supplement part 2: Evaluation of a new cosmetic topical formulation in the management of irritant diaper dermatitis in infants. Panthenol comes from pantothenic acid. These compounds naturally help your skin and hair look and feel better. By using products with panthenol in them your hair might look shinier and feel fuller. Loftus, E. V., Jr., Tremaine, W. J., Nelson, R. A., Shoemaker, J. D., Sandborn, W. J., Phillips, S. F., and Hasan, Y. Dexpanthenol enemas in ulcerative colitis: a pilot study. Mayo Clin.Proc. 1997;72(7):616-620. View abstract.
Panthenol is a common ingredient found in personal care products created for hair, skin and nails. It is often used in products such as lotions, moisturizers, serums, shampoos, conditioners, nail treatments and hand creams. What is panthenol used for? A 2020 review on the role of panthenol, or dexpanthenol, on wound healing states that it is excellent for post-procedural wounds, especially when used immediately after skin damage. Boosts skin barrier function Gulhas, N., Canpolat, H., Cicek, M., Yologlu, S., Togal, T., Durmus, M., and Ozcan, Ersoy M. Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat. Acta Anaesthesiol.Scand. 2007;51(2):239-243. View abstract. Panthenol may have anti-inflammatory benefits to the skin as well. There have been some studies that suggest that it may help reduce the appearance of UV-induced redness and may alleviate the itching associated with dermatitis. What Are The Misconceptions About Panethnol?Clinical studies have shown the evaluation of dexpanthenol in wound healing applications. These small clinical trials used the drug as a pastille and or spray to heal wounds in postoperative endotracheal intubation, endoscopic sinus surgery, and tonsillectomy. [7] [8] [9]The useof dexpanthenol shows better clinical outcomes in these clinical trials. Regardless, further studies are necessary to generalize drug efficacy.
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