Pure Source Nutrition Pure Sodium Ascorbate Food Buffered Vitamin C Powder Food Grade 1kg / 1000g

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Numer At baseline, the plasma concentration of VEGFα, IL-10, IL-6 and IL-8 were similar between groups (Additional file 1: Fig. S3). The baseline plasma CRP concentration was numerically higher in the NaAscorbate group at a median of 607 mg/L compared with 308 mg/L in the control group. The temporal changes, however, were similar between the two groups with a significant decrease for IL-6 and IL-8 in both groups ( P< 0.001 and P = 0.0012, respectively) (Additional file 1: Figs. S3 and S4). Biochemical outcomes analysis Note that the Tolerable Upper Intake Level (UL) for vitamin C for men and women ages 19 years and older is 2,000 mg. That said, some people experience side effects with frequent and prolonged intake of 1,000 mg per day ( 1, 2, 15). For the European Union, the EFSA set higher recommendations for adults, and also for children: 20mg/day for ages 1–3, 30mg/day for ages 4–6, 45mg/day for ages 7–10, 70mg/day for ages 11–14, 100mg/day for males ages 15–17, 90mg/day for females ages 15–17. For pregnancy 100mg/day; for lactation 155mg/day. [83] Gombart AF, Pierre A et al. A review of micronutrients and the immune system – Working in harmony to reduce the risk of infection. Nutrients 2020 Jan; 12(1): 236

Fowler AA 3rd, Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, Farthing CA, Larus TL, Martin E, Brophy DF, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med. 2014;12(1):32. Frei B., Birlouez-Aragon I., Lykkesfeldt J. Authors’ perspective: What is the optimum intake of vitamin C in humans? Crit. Rev. Food Sci. Nutr. 2012; 52: 815 – 829Some professional-grade brands can be expensive, but keep in mind that a higher price doesn’t necessarily mean a better product. Time-release vitamin C is often the preferred choice since vitamin C has better bioavailability when taken in smaller doses throughout the day. A time-release formula aims to solve this problem without taking multiple tablets, by releasing the vitamin C slowly throughout the day. Reintam Blaser A, Alhazzani W, Belley-Cote E, Moller MH, Adhikari NKJ, Burry L, Coopersmith CM, Al Duhailib Z, Fujii T, Granholm A, et al. Intravenous vitamin C therapy in adult patients with sepsis: a rapid practice guideline. Acta Anaesthesiol Scand. 2023. https://doi.org/10.1111/aas.14311.

A possible explanation for our findings might relate to the amount of the study drug administered. In our study, for example, the median serum vitamin C (measured as ascorbate) concentration was approximated 6000 µmol/L. This is more than 30 times higher than in the CITRIS-ALI trial [ 10]. Achieving very high blood levels might affect the capacity of ascorbate to affect biological pathways as suggested by a recent systematic review [ 24, 25, 26], and as shown in experimental studies, where complete resolution of sepsis was achieved in a few hours with ascorbate concentrations of approximately 10,000 µmol/L [ 16]. For this reason, ascorbic acid is much more acidic than would be expected if the compound contained only isolated hydroxyl groups. Ascorbic acid is easily oxidized and so is used as a reductant in photographic developer solutions (among others) and as a preservative. A Simple Test for Vitamin C" (PDF). School Science Review. 83 (305): 131. 2002. Archived from the original (PDF) on July 4, 2016.

Meanwhile, liposomal vitamin C is a form encapsulated in liposomes, a small vesicle made from cholesterol or other phospholipids. These supplements can help increase the absorption of vitamin C, but they are also often more expensive ( 14, 17).

Additionally, a systematic review found that vitamin C supplementation was effective in lowering blood pressure in people with hypertension ( 5). Vitamin C blood serum levels are considered saturated at levels >65 μmol/L (1.1mg/dL), achieved by consuming amounts which are at, or above, the Recommended Dietary Allowance, while adequate levels are defined as ≥50 μmol/L. Hypovitaminosis of vitamin C is defined as ≤23 μmol/L and deficiency occurs at ≤11.4 μmol/L. [29] [30] For those 20 years of age or above, data from the U.S. 2003–04 National Health and Nutrition Examination Survey showed mean and median serum concentrations of 49.0 and 54.4 μmol/L, respectively. The percent of people reported as deficient was 7.1%. [30]SVCTs appear to be the predominant system for vitamin C transport in the body, [129] the notable exception being red blood cells, which lose SVCT proteins during maturation. [132] In both vitamin C synthesizers (example: rat) and non-synthesizers (example: human) cells with few exceptions maintain ascorbic acid concentrations much higher than the approximately 50 micromoles/liter (µmol/L) found in plasma. For example, the ascorbic acid content of pituitary and adrenal glands can exceed 2,000µmol/L, and muscle is at 200–300µmol/L. [133] The known coenzymatic functions of ascorbic acid do not require such high concentrations, so there may be other, as yet unknown functions. A consequence of all this high concentration organ content is that plasma vitamin C is not a good indicator of whole-body status, and people may vary in the amount of time needed to show symptoms of deficiency when consuming a diet very low in vitamin C. [133]