Molecular Biology of the Cell

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Anchoring Junctions Formed by Integrins Bind Cells to the Extracellular Matrix: Focal Adhesions and Hemidesmosomes A Comparison of Human and Mouse Chromosomes Shows How The Large-scale Structures of Genomes Diverge Bacterial Chemotaxis Depends on a Two-Component Signaling Pathway Activated by Histidine-Kinase-associated Receptors

Long-term Potentiation (LTP) in the Mammalian Hippocampus Depends on Ca 2+ Entry Through NMDA-Receptor Channels Most Proteins Synthesized in the Rough ER Are Glycosylated by the Addition of a Common N-linked Oligosaccharide Other Polymeric Proteins Also Use Nucleotide Hydrolysis to Couple a Conformational Change to Cell Movements Four Familiar Signaling Pathways Combine to Pattern the Wing Disc: Wingless, Hedgehog, Dpp, and Notch The Plasma Membrane Contains Lipid Rafts That Are Enriched in Sphingolipids, Cholesterol, and Some Membrane ProteinsPolarized Cells Direct Proteins from the Trans Golgi Network to the Appropriate Domain of the Plasma Membrane For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). Current Therapies Exploit the Loss of Cell-Cycle Control and the Genetic Instability of Cancer Cells

Some Key Regulatory Genes Define a Cell Type; Others Can Activate the Program for Creation of an Entire Organ There Are Multiple Homologs of the RecA Protein in Eucaryotes, Each Specialized for a Specific Function The Photosynthetic Electron-transport Chains of Cyanobacteria Produced Atmospheric Oxygen and Permitted New Life-Forms Molecular Biology of the Cell is a cellular and molecular biology textbook published by W.W. Norton & Co and currently authored by Bruce Alberts, Rebecca Heald, David Morgan, Martin Raff, Keith Roberts and Peter Walter. The book was first published in 1983 by Garland Science and is now in its seventh edition. The molecular biologist James Watson contributed to the first three editions.

of one molecule can align to points a 2, b 2, and c 2 in the other molecule, respectively. Which map As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. Read more... Anchoring Junctions Connect the Cytoskeleton of a Cell Either to the Cytoskeleton of Its Neighbors or to the Extracellular Matrix The Mammalian DNA Sequences That Specify the Initiation of Replication Have Been Difficult to Identify

Initial Patterns Are Established in Small Fields of Cells and Refined by Sequential Induction as the Embryo Grows Extracellular Signals Are Greatly Amplified by the Use of Small Intracellular Mediators and Enzymatic Cascades Nucleic Acid Hybridization Reactions Provide a Sensitive Way of Detecting Specific Nucleotide SequencesIn a Reaction Center, Light Energy Captured by Chlorophyll Creates a Strong Electron Donor from a Weak One Transport Between the Nucleus and Cytosol Can Be Regulated by Controlling Access to the Transport Machinery motif called a leucine zipper, each of the two participating ³ helices has a leucine residue at every Interactions of the Oocyte With Its Surroundings Define the Axes of the Embryo: the Role of the Egg-Polarity Genes