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Furthermore, denbinobin significantly suppressed the expression of Bcr-Abl and phosphorylation of CrkL, a crucial tyrosinase kinase and an adaptor protein in chronic myeloid leukemia, respectively [ 45].

Indeed, a large number of pharmacological activities were assigned to different Dendrobium species, such as anti-inflammatory [ 5], anti-platelet aggregation [ 6], hepatoprotective [ 7], anti-fibrotic [ 8], anti-viral [ 9], anti-fungal [ 10], antimicrobial [ 11], antioxidant [ 12- 14], anti-diabetic [ 15], neuroprotective [ 16], immunomodulatory and anticancer [ 17]. Evidently, it is necessary to use the same animal model, administered with extracts from the same extraction procedure at the same dosages for the same period to correctly evaluate the capability of different Dendrobium polysaccharides to decrease blood sugar levels. Overexpression of CD proteins in diabetic patients provides a fertile environment for tumor growth and differentiation. This type of orchid is native to China, Hong Kong, Taiwan, India, Thailand, Vietnam, and other temperate and tropical Asian regions. loddigesii were assessed on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo [ 34].candidum extract would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms [ 108]. This study also showed that erianin at low dosages (10 and 20 nM) could suppress migration of T47D cells effectively. Thus, the investigations for new treatments have been focused on natural compounds with hypoglycemic or anti-glycation activities, α-glucosidase inhibitors etc.

A structural modification of stem mucilage polysaccharide by deacetylation of 2- O-glucomannan was investigated whether it would affect its stimulatory effect on cytokine production. Treatment of cells with deacetylated stem mucilage was found to maintain cell proliferation, but fail to induce cytokine production.You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

Extraction methods of polysaccharides may change their chemical properties and so biological activities.Amongst other studies on anticancer agents from Dendrobium plants, a MeOH extract obtained from a whole plant of D.

in different proportions were prepared and administrated to diabetic rats over a total period of 48 days.Traditional Chinese Medicine (TCM): Dendrobium species, particularly Dendrobium nobile, have been used in TCM to treat conditions like fever, diabetes, Asthma, Allergy and certain eye problems due to It's cooling properties Ayurveda: In some Ayurvedic preparations, dendrobium is used as a tonic for enhancing physical and mental stamina. The inhibitory effects and cytotoxicity of erianin in OS cells was evaluated on various OS cell lines (143B, MG63. but where very important for the expression of the immunological activity of DNP-W5, which displayed remarkable immunoenhancing activities on T- and B-lymphocytes [ 95]. The protective effect of DO in diabetic rats may be associated with its antioxidant activity, as evidenced by the marked increase in the serum level of GSH-PX. officinale could downregulate the expression of malondialdehyde and 8-hydroxy-2-deoxyguanosine and up-regulate the activity of glutathione peroxidase as well as IL-2 during N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric tumorigenesis in rats.